Human SH2 domain-containing protein 4B (SH2D4B) ELISA Kit

Name: Human SH2 domain-containing protein 4B (SH2D4B) ELISA Kit
Brand: Abbexa
SKU: abx545639
Price: 715 EUR
Availability: OnlineOnly

Este producto es parte de SH2D - SH2 domain containing

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for SH2D4B

proveedor

Abbexa

reference

abx545639

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human SH2 domain-containing protein 4B (SH2D4B) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human SH2 domain-containing protein 4B (SH2D4B) concentrations in serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.

Background

SH2D4B is an SH2 domain-containing adaptor protein that functions as a modulator of cytokine and receptor tyrosine kinase signaling pathways. It negatively regulates signaling cascades such as JAK/STAT and PI3K/Akt by binding to phosphotyrosine residues on activated receptors or signaling intermediates, attenuating downstream signaling. SH2D4B is expressed in various tissues, including hematopoietic and epithelial cells, where it controls cellular proliferation, differentiation, and immune responses. It acts as a tumor suppressor by inhibiting excessive signaling that promotes cell survival and uncontrolled proliferation. Dysregulation or loss of SH2D4B expression is associated with cancer progression and immune dysfunction due to hyperactive cytokine signaling and impaired negative feedback regulation. Knockdown studies reveal increased cell proliferation, altered cytokine responses, and enhanced tumor growth, highlighting its role as a critical negative regulator of signal transduction and cellular homeostasis.

Características del producto

immunogen target

SH2 domain-containing protein 4B (SH2D4B)

reactivity

Human

test range

0.156 ng/ml - 10 ng/ml

assay data

Quantitative

form

Lyophilized

detection method

Colorimetric

sample type

Serum, plasma, tissue homogenates, cell culture supernatants and other biological fluids.

size 1

96 tests

alias

SH2D4B

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

SH2D4B

dry ice

uniprot id

https://www.uniprot.org/uniprotkb/Q5SQS7

note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

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SH2D4B Antibody

proveedor

Abbexa

reference

abx026496

Tested Applications

ELISA, WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

The function of this protein remains unknown.

292.5€ (80 µl)