SH2D1A Antibody is a Rabbit Polyclonal antibody against SH2D1A. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Primary Antibodies
Polyclonal
Human, Mouse
SH2 Domain Containing 1A (SH2D1A)
Rabbit
Unconjugated
Liquid
WB, IF/ICC
Purified by affinity chromatography.
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
20 µl
50 µl
100 µl
200 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
SH2D1A
No
Shipped within 5-10 working days.
SH2D1A,DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A,SLAM associated protein
NP_002342.1
This product is for research use only.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein cont...
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Ver másSH2D1A Antibody is a Rabbit Polyclonal antibody against SH2D1A. This gene encodes a protein that plays a major role in t...
175€ (20 µl)
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