Mouse SH2 Domain Containing Protein 1A (SH2D1A) Protein

Este producto es parte de SH2D - SH2 domain containing
Mouse SH2 Domain Containing Protein 1A (SH2D1A) Protein

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935106861

info@markelab.com

Precio

247€ (10 µg)

Protein SH2D1A

proveedor

Abbexa

reference

abx069054

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant SH2 Domain Containing Protein 1A (SH2D1A) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

SH2D1A, also known as SAP (SLAM-associated protein), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM (Signaling Lymphocyte Activation Molecule) family receptors. It is predominantly expressed in T cells, NK cells, and other immune cells, where it plays a crucial role in immune cell activation, cytotoxicity, and cytokine production. SH2D1A binds to the cytoplasmic tails of SLAM receptors, modulating T-cell receptor (TCR) signaling, NK cell activation, and germinal center formation. Mutations or deletions in SH2D1A cause X-linked lymphoproliferative syndrome (XLP), a severe immunodeficiency characterized by uncontrolled lymphocyte proliferation, impaired antibody responses, and susceptibility to Epstein-Barr virus (EBV) infections. SH2D1A also regulates immune synapse formation and T-cell-B-cell interactions, ensuring proper immune homeostasis. Knockout studies reveal defects in immune cell activation, abnormal germinal center development, and impaired antiviral responses, underscoring its essential role in immune regulation.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

SH2 Domain Containing Protein 1A (SH2D1A)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 14.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys18-Gly115 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

SH2D1A


dry ice

No


availability

Shipped within 5-7 working days.


alias

SH2D1A,DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A,SLAM associated protein


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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