Mouse SH2 Domain Containing Protein 1A (SH2D1A) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein SH2D1A
proveedor
Abbexareference
abx069054Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant SH2 Domain Containing Protein 1A (SH2D1A) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Background
SH2D1A, also known as SAP (SLAM-associated protein), is an SH2 domain-containing adaptor protein that regulates signaling pathways downstream of SLAM (Signaling Lymphocyte Activation Molecule) family receptors. It is predominantly expressed in T cells, NK cells, and other immune cells, where it plays a crucial role in immune cell activation, cytotoxicity, and cytokine production. SH2D1A binds to the cytoplasmic tails of SLAM receptors, modulating T-cell receptor (TCR) signaling, NK cell activation, and germinal center formation. Mutations or deletions in SH2D1A cause X-linked lymphoproliferative syndrome (XLP), a severe immunodeficiency characterized by uncontrolled lymphocyte proliferation, impaired antibody responses, and susceptibility to Epstein-Barr virus (EBV) infections. SH2D1A also regulates immune synapse formation and T-cell-B-cell interactions, ensuring proper immune homeostasis. Knockout studies reveal defects in immune cell activation, abnormal germinal center development, and impaired antiviral responses, underscoring its essential role in immune regulation.
Características del producto
category
Proteins and Peptides
origin
Mouse
host
E. coli
immunogen target
SH2 Domain Containing Protein 1A (SH2D1A)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 14.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys18-Gly115 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SH2D1A
dry ice
No
availability
Shipped within 5-7 working days.
alias
SH2D1A,DSHP, EBVS, IMD5, LYP, MTCP1, SAP, SAP/XLP, XLPD, XLPD1, SH2 domain containing 1A,SLAM associated protein
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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