Serpin Peptidase Inhibitor, Clade I Member 1 Protein

Este producto es parte de SERPINI1 - serpin family I member 1
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234€ (5 µg)

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935106861
info@markelab.com
name
Serpin Peptidase Inhibitor, Clade I Member 1 Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx261371
tested applications
SDS-PAGE

Description

SERPINI1 is a recombinant protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
SERPINI1
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 97% (SDS-PAGE and RP-HPLC)
Size 1
5 µg
Size 2
20 µg
Size 3
1 mg
Form
Lyophilized 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
UniProt ID
Q99574
Alias
PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1
Background
Protein SERPINI1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SERPINI1 (serpin family I member 1) is a gene encoding the neuroserpin protein, a member of the serpin (serine protease inhibitor) superfamily. Unlike many other serpins, neuroserpin is primarily expressed in the central nervous system, where it plays a critical role in regulating proteolytic activity, particularly by inhibiting tissue-type plasminogen activator (tPA). The balance between neuroserpin and tPA is crucial for neural development, synaptic plasticity, and maintaining the integrity of neuronal tissues. SERPINI1 mutations are associated with certain neurodegenerative diseases, notably familial encephalopathy with neuroserpin inclusion bodies (FENIB), a condition characterized by the accumulation of misfolded neuroserpin proteins in neurons. This leads to neurodegeneration, progressive cognitive decline, and other neurological impairments.

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