Mouse Neuroserpin (SerpinI1) Protein

Este producto es parte de SERPINI1 - serpin family I member 1
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1079€ (50 µg)

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935106861
info@markelab.com
name
Mouse Neuroserpin (SerpinI1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692199
tested applications
SDS-PAGE

Description

Mouse SerpinI1 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse SERPINI1 (O35684) (Met 1-Leu 410) was expressed, with a C-terminal polyhistidine tag.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
SerpinI1
Host
HEK293 cells
Origin
Mouse
Observed MW
Molecular Weight: 46 kDa
Sequence Fragment: Met1-Leu410
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
50 µg
Form
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
O35684
Alias
PI12,HNS-S1,HNS-S2,neuroserpin,Peptidase inhibitor 12,Serpin I1
Background
Protein SERPINI1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SERPINI1 (serpin family I member 1) is a gene encoding the neuroserpin protein, a member of the serpin (serine protease inhibitor) superfamily. Unlike many other serpins, neuroserpin is primarily expressed in the central nervous system, where it plays a critical role in regulating proteolytic activity, particularly by inhibiting tissue-type plasminogen activator (tPA). The balance between neuroserpin and tPA is crucial for neural development, synaptic plasticity, and maintaining the integrity of neuronal tissues. SERPINI1 mutations are associated with certain neurodegenerative diseases, notably familial encephalopathy with neuroserpin inclusion bodies (FENIB), a condition characterized by the accumulation of misfolded neuroserpin proteins in neurons. This leads to neurodegeneration, progressive cognitive decline, and other neurological impairments.
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