Serpin Family E Member 1 (SERPINE1) Antibody

Este producto es parte de SERPINE1 - serpin family E member 1
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637€ (100 µl)

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935106861
info@markelab.com
name
Serpin Family E Member 1 (SERPINE1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx115473
tested applications
ELISA, WB, IHC

Description

Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Antibody is a Rabbit Polyclonal antibody against Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetSerpin Family E Member 1 (SERPINE1)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 1100 µl
FormLiquid
Tested ApplicationsELISA, WB, IHC
BufferPBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP05121
Gene ID5054
NCBI AccessionNP_000593.1, NM_000602.4
OMIM173360
AliasPAI,PAI1,PAI-1,PLANH1,Plasminogen activator inhibitor 1,Endothelial plasminogen activator inhibitor,Serpin E1
BackgroundAntibody anti-SERPINE1
StatusRUO

SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI1), is a serine protease inhibitor that plays a key role in the regulation of fibrinolysis, the process that breaks down blood clots. It belongs to the serpin superfamily, which is a group of proteins involved in the inhibition of proteases. Specifically, SERPINE1 inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), both of which are enzymes responsible for converting plasminogen into plasmin, a protease that degrades fibrin, the main component of blood clots. The regulation of PAI-1 levels is crucial for maintaining the balance between clot formation and breakdown in the body. Abnormally high levels of PAI-1 are associated with thrombotic conditions, whereas deficiencies can lead to excessive bleeding.

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