Plasminogen Activator Inhibitor 1 (SERPINE1) Antibody

Este producto es parte de SERPINE1 - serpin family E member 1
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273€ (100 µl)

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935106861
info@markelab.com
name
Plasminogen Activator Inhibitor 1 (SERPINE1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx132062
tested applications
WB, IHC, IF/ICC

Description

Plasminogen Activator Inhibitor 1 Antibody is a Mouse Monoclonal against Plasminogen Activator Inhibitor 1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

CategoryPrimary Antibodies
Immunogen TargetPlasminogen Activator Inhibitor 1 (SERPINE1)
HostMouse
ReactivityHuman
Recommended DilutionWB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
ConjugationUnconjugated
IsotypeIgG2a Kappa
PurificationPurified by Protein A and Protein G affinity chromatography.
Size 1100 µl
Size 2200 µl
Size 31 ml
FormLiquid
Tested ApplicationsWB, IHC, IF/ICC
Buffer0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
AvailabilityShipped within 5-7 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP05121
AliasPAI,PAI1,PAI-1,PLANH1,Plasminogen activator inhibitor 1,Endothelial plasminogen activator inhibitor,Serpin E1
BackgroundAntibody anti-SERPINE1
StatusRUO
NoteConcentration: 0.76 mg/ml -

Descripción

SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI1), is a serine protease inhibitor that plays a key role in the regulation of fibrinolysis, the process that breaks down blood clots. It belongs to the serpin superfamily, which is a group of proteins involved in the inhibition of proteases. Specifically, SERPINE1 inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), both of which are enzymes responsible for converting plasminogen into plasmin, a protease that degrades fibrin, the main component of blood clots. The regulation of PAI-1 levels is crucial for maintaining the balance between clot formation and breakdown in the body. Abnormally high levels of PAI-1 are associated with thrombotic conditions, whereas deficiencies can lead to excessive bleeding.

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