Plasminogen Activator Inhibitor 1 (SERPINE1) Antibody
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935106861
info@markelab.com
Precio
273€ (100 µl)
Antibody anti-SERPINE1
proveedor
Abbexareference
abx132062Tested Applications
WB, IHC, IF/ICCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
Plasminogen Activator Inhibitor 1 Antibody is a Mouse Monoclonal against Plasminogen Activator Inhibitor 1.
Background
SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI1), is a serine protease inhibitor that plays a key role in the regulation of fibrinolysis, the process that breaks down blood clots. It belongs to the serpin superfamily, which is a group of proteins involved in the inhibition of proteases. Specifically, SERPINE1 inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), both of which are enzymes responsible for converting plasminogen into plasmin, a protease that degrades fibrin, the main component of blood clots. The regulation of PAI-1 levels is crucial for maintaining the balance between clot formation and breakdown in the body. Abnormally high levels of PAI-1 are associated with thrombotic conditions, whereas deficiencies can lead to excessive bleeding.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Plasminogen Activator Inhibitor 1 (SERPINE1)
host
Mouse
isotype
IgG2a Kappa
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by Protein A and Protein G affinity chromatography.
recommended dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
100 µl
size 2
200 µl
size 3
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SERPINE1
dry ice
No
availability
Shipped within 5-7 working days.
alias
PAI,PAI1,PAI-1,PLANH1,Plasminogen activator inhibitor 1,Endothelial plasminogen activator inhibitor,Serpin E1
uniprot id
note
Concentration: 0.76 mg/ml -
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