Serpin B5 (SERPINB5) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Serpin B5 (SERPINB5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx026594
tested applications
ELISA, WB, IHC, IF/ICC
Description
SERPINB5 is a tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Serpin B5 (SERPINB5) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P36952 |
| Alias | PI5,maspin,Serpin B5,Peptidase inhibitor 5 |
| Background | Antibody anti-SERPINB5 |
| Status | RUO |
Descripción
SERPINB5, also known as maspin (mammary serine protease inhibitor), is a member of the serpin (serine protease inhibitor) superfamily. Unlike many other serpins that function as protease inhibitors, SERPINB5 is unique in that it does not inhibit protease activity. Discovered in the early 1990s, SERPINB5 has since been the subject of extensive research due to its involvement in various cellular processes and its implications in cancer biology. This protein is encoded by the SERPINB5 gene located on chromosome 18q21.3, a region that has been associated with several types of cancer, particularly breast cancer. SERPINB5 is primarily expressed in epithelial cells and has been implicated in processes such as cell adhesion, migration, and apoptosis.
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