Serine--Pyruvate Aminotransferase (AGXT) Antibody

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312€ (60 µl)

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935106861
info@markelab.com
name
Serine--Pyruvate Aminotransferase (AGXT) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx005823
tested applications
WB

Description

AGXT Antibody is a Rabbit Polyclonal Antibody against AGXT.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Serine--Pyruvate Aminotransferase (AGXT)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
60 µl
Size 2
120 µl
Size 3
200 µl
Form
Liquid
Tested Applications
WB
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P21549
Gene ID
189
NCBI Accession
NP_000021.1
Alias
AGXT, AGT1, SPAT
Background
Antibody anti-AGXT
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

Alanine-glyoxylate aminotransferase (AGXT) is a pyridoxal phosphate-dependent enzyme localized in peroxisomes, where it plays a critical role in detoxifying glyoxylate by converting it into glycine, using alanine as an amino donor. AGXT is central to preventing the overproduction of oxalate, a byproduct of glyoxylate metabolism, which, if accumulated, can form calcium oxalate crystals leading to kidney stones and renal damage. Mutations in the AGXT gene cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by excessive oxalate production, kidney stone formation, and systemic oxalosis. AGXT's activity is regulated by intracellular localization and metabolic cues, and therapies targeting AGXT include enzyme replacement therapy and gene therapy to restore glyoxylate metabolism in affected individuals.

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