AGXT antibody
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935106861
info@markelab.com
name
AGXT antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00224
tested applications
ELISA, IHC, WB
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | alanine-glyoxylate aminotransferase (AGXT) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 43 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P21549 |
| Gene ID | 189 |
| Alias | AGXT, AGT1, SPAT |
| Background | Antibody anti-AGXT |
| Status | RUO |
| Note | Mol. Weight 43 kDa |
Alanine-glyoxylate aminotransferase (AGXT) is a pyridoxal phosphate-dependent enzyme localized in peroxisomes, where it plays a critical role in detoxifying glyoxylate by converting it into glycine, using alanine as an amino donor. AGXT is central to preventing the overproduction of oxalate, a byproduct of glyoxylate metabolism, which, if accumulated, can form calcium oxalate crystals leading to kidney stones and renal damage. Mutations in the AGXT gene cause primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder characterized by excessive oxalate production, kidney stone formation, and systemic oxalosis. AGXT's activity is regulated by intracellular localization and metabolic cues, and therapies targeting AGXT include enzyme replacement therapy and gene therapy to restore glyoxylate metabolism in affected individuals.
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