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Semaphorin 3B (SEMA3B) Antibody
proveedor
Abbexareference
abx006412Tested Applications
WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalDescripción
SEMA3B Antibody is a Rabbit Polyclonal Antibody against SEMA3B.
Background
Semaphorins constitute a large family of cell surface and secreted guidance molecules, categorized into eight classes due to their structural variations, They show a conserved sema domain in their N-terminal region. They primarily function as short-range inhibitory signals, particularly crucial in directing axons away from inappropriate areas, especially during neural system development. Plexins are the primary receptors for semaphorins, often working alongside neuropilins as co-receptors in receptor complexes. These molecules have various roles, and some classes of semaphorins (SEMA3,SEMA4,SEMA4,SEMA6 ,SEMA7)are found in vertebrates, contributing to processes like atherosclerosis by affecting endothelial function, leukocyte infiltration, monocyte-macrophage retention, platelet hyperreactivity, and neovascularization. SEMA3B serves as an inhibitor of axonal extension and has demonstrated its role as a tumor suppressor by promoting apoptosis. Different transcript variants are produced due to alternative splicing of this gene. It is known by various aliases, including SemA, SEMA5, SEMAA, semaV, and LUCA-1.
Background
Las semaforinas constituyen una gran familia de moléculas guía secretadas y de superficie celular, clasificadas en ocho clases debido a sus variaciones estructurales. Muestran un dominio sema conservado en su región N-terminal. Funcionan principalmente como señales inhibidoras de corto alcance, particularmente cruciales para alejar los axones de áreas inapropiadas, especialmente durante el desarrollo del sistema neuronal. Las plexinas son los receptores principales de las semaforinas y a menudo trabajan junto con las neuropilinas como correceptores en complejos receptores. Estas moléculas tienen varias funciones y algunas clases de semaforinas (SEMA3, SEMA4, SEMA4, SEMA6, SEMA7) se encuentran en los vertebrados y contribuyen a procesos como la aterosclerosis al afectar la función endotelial, la infiltración de leucocitos, la retención de monocitos y macrófagos, la hiperreactividad plaquetaria y la neovascularización. . SEMA3B actúa como inhibidor de la extensión axonal y ha demostrado su papel como supresor de tumores al promover la apoptosis. Se producen diferentes variantes de transcripción debido al corte y empalme alternativo de este gen. Es conocido por varios alias, incluidos SemA, SEMA5, SEMAA, semaV y LUCA-1.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse
immunogen target
Semaphorin 3B (SEMA3B)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB
purification
Purified by affinity chromatography.
buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
SEMA3B
dry ice
No
availability
Shipped within 5-10 working days.
alias
SemA,SEMA5,SEMAA,semaV,LUCA-1,Sema A(V),Semaphorin-V,Semaphorin-3B
uniprot id
NCBI accession
NP_001005914.1
note
This product is for research use only.
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