Ring Finger Protein, Lim Domain Interacting (RLIM) Antibody
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Description
Ring Finger Protein, Lim Domain Interacting Antibody is a Rabbit Polyclonal antibody against Ring Finger Protein, Lim Domain Interacting.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ring Finger Protein, Lim Domain Interacting (RLIM) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NVW2 |
| Gene ID | 51132 |
| NCBI Accession | NP_057204.2, NM_016120.3, NP_899196.1, NM_183353.2 |
| OMIM | 300379 |
| Background | Antibody anti-RLIM |
| Status | RUO |
Descripción
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E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
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Ring Finger Protein, Lim Domain Interacting (RLIM) Antibody
Ring Finger Protein, Lim Domain Interacting Antibody is a Rabbit Polyclonal antibody against Ring Finger Protein, Lim Domain Interacting.
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