RLIM antibody
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Description
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ring finger protein, LIM domain interacting (RLIM) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 75 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NVW2 |
| Gene ID | 51132 |
| Alias | E3 ubiquitin-protein ligase RLIM,LIM domain-interacting RING finger protein,RING finger LIM domain-binding protein (R-LIM),RING finger protein 12,RING-type E3 ubiquitin transferase RLIM,Renal carcinoma antigen NY-REN-43,RLIM,RNF12 |
| Background | Antibody anti-RLIM |
| Status | RUO |
| Note | Mol. Weight 75 kDa |
Descripción
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