Rhodopsin (RHO) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Rhodopsin (RHO) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015395
tested applications
WB
Description
Rabbit polyclonal antibody against RHO protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rhodopsin (RHO) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08100 |
| Alias | RHO,RP4,OPN2,CSNBAD1 |
| Background | Antibody anti-RHO |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Rhodopsin (RHO) is a light-sensitive G protein-coupled receptor found in the rod cells of the retina, which plays a crucial role in vision, especially in low-light conditions. It is composed of the protein opsin and a retinal chromophore. When light hits rhodopsin, the retinal undergoes a conformational change, activating the opsin and initiating a signaling cascade that results in hyperpolarization of the rod cell and the transmission of visual signals to the brain. Rhodopsin is highly sensitive to light, making it essential for scotopic vision, or vision in dim light. Mutations in the RHO gene can lead to various retinal diseases, including retinitis pigmentosa, which causes progressive vision loss and, eventually, blindness. Research into rhodopsin and its mechanisms is important for understanding retinal diseases and developing potential therapies to treat them, including gene therapies and pharmacological interventions to restore or protect vision.
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