Relaxin/Insulin Like Family Peptide Receptor 2 (RXFP2) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Relaxin/Insulin Like Family Peptide Receptor 2 (RXFP2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx328076
tested applications
ELISA, WB, IF/ICC
Description
RXFP2 Antibody is a Rabbit Polyclonal against RXFP2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Relaxin/Insulin Like Family Peptide Receptor 2 (RXFP2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WXD0 |
| Gene ID | 122042 |
| Alias | RXFP2,GPR106,RXFPR2,relaxin receptor 2,LGR8,INSL3 receptor,leucine-rich repeat-containing G protein-coupled receptor 8,relaxin/insulin like family peptide receptor 2,GREAT, INSL3R, LGR8, LGR8.1 |
| Background | Antibody anti-RXFP2 |
| Status | RUO |
Descripción
RXFP2 is another member of the relaxin/insulin-like family peptide receptors, activated by relaxin-2 and its analogs. RXFP2 primarily couples to Gs proteins, stimulating adenylate cyclase to increase cAMP levels and induce downstream effects such as smooth muscle relaxation, vasodilation, and remodeling of tissues. RXFP2 is expressed in various tissues, including the brain, reproductive system, and heart, where it is involved in regulating reproductive functions such as ovulation, pregnancy, and labor, as well as maintaining vascular tone. RXFP2 also plays a key role in modulating heart function by influencing cardiac remodeling, fibrosis, and endothelial function. Dysregulation of RXFP2 signaling has been implicated in cardiovascular diseases, infertility, and pregnancy complications. Targeting RXFP2 with agonists or antagonists holds promise for treating conditions such as heart failure, preterm labor, and fibrotic diseases by promoting tissue remodeling and vascular homeostasis.
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