Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) Antibody
357.5€ (100 µg)
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935106861
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name
Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122948
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the RXFP1 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC113617 |
| Alias | RXFP1,LGR7,RXFPR1,relaxin receptor 1,leucine-rich repeat-containing G-protein-coupled receptor 7,RX1,relaxin/insulin like family peptide receptor 1 |
| Background | Antibody anti-RXFP1 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
RXFP1 is a G protein-coupled receptor activated by relaxin, a peptide hormone involved in reproductive, cardiovascular, and renal physiology. RXFP1 primarily couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels, which in turn affects smooth muscle relaxation, vasodilation, and cell proliferation. RXFP1 is expressed in the reproductive tissues, kidneys, and blood vessels, where it plays a role in pregnancy, cardiac remodeling, and kidney function. During pregnancy, RXFP1 helps modulate uterine relaxation and cervical ripening. In cardiovascular health, RXFP1 is involved in regulating blood pressure and maintaining vascular integrity. Dysregulation of RXFP1 is linked to pregnancy complications, hypertension, and fibrosis. As a target for cardiovascular and renal diseases, RXFP1 receptor agonists are being explored for their potential in promoting tissue repair and reducing fibrosis, while antagonists could be used to modulate pregnancy-related vascular changes.
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