Human Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) Protein

Este producto es parte de LGR - Leucine Rich Repeat Containing G Protein-Coupled Receptor
Human Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein RXFP1

proveedor

Abbexa

reference

abx068858

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

RXFP1 is a G protein-coupled receptor activated by relaxin, a peptide hormone involved in reproductive, cardiovascular, and renal physiology. RXFP1 primarily couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels, which in turn affects smooth muscle relaxation, vasodilation, and cell proliferation. RXFP1 is expressed in the reproductive tissues, kidneys, and blood vessels, where it plays a role in pregnancy, cardiac remodeling, and kidney function. During pregnancy, RXFP1 helps modulate uterine relaxation and cervical ripening. In cardiovascular health, RXFP1 is involved in regulating blood pressure and maintaining vascular integrity. Dysregulation of RXFP1 is linked to pregnancy complications, hypertension, and fibrosis. As a target for cardiovascular and renal diseases, RXFP1 receptor agonists are being explored for their potential in promoting tissue repair and reducing fibrosis, while antagonists could be used to modulate pregnancy-related vascular changes.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 19.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro110-Ala259 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

RXFP1


dry ice

No


availability

Shipped within 5-12 working days.


alias

RXFP1,LGR7,RXFPR1,relaxin receptor 1,leucine-rich repeat-containing G-protein-coupled receptor 7,RX1,relaxin/insulin like family peptide receptor 1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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