Human Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein RXFP1
proveedor
Abbexareference
abx068858Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
RXFP1 is a G protein-coupled receptor activated by relaxin, a peptide hormone involved in reproductive, cardiovascular, and renal physiology. RXFP1 primarily couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels, which in turn affects smooth muscle relaxation, vasodilation, and cell proliferation. RXFP1 is expressed in the reproductive tissues, kidneys, and blood vessels, where it plays a role in pregnancy, cardiac remodeling, and kidney function. During pregnancy, RXFP1 helps modulate uterine relaxation and cervical ripening. In cardiovascular health, RXFP1 is involved in regulating blood pressure and maintaining vascular integrity. Dysregulation of RXFP1 is linked to pregnancy complications, hypertension, and fibrosis. As a target for cardiovascular and renal diseases, RXFP1 receptor agonists are being explored for their potential in promoting tissue repair and reducing fibrosis, while antagonists could be used to modulate pregnancy-related vascular changes.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Relaxin/Insulin Like Family Peptide Receptor 1 (RXFP1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 19.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro110-Ala259 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
RXFP1
dry ice
No
availability
Shipped within 5-12 working days.
alias
RXFP1,LGR7,RXFPR1,relaxin receptor 1,leucine-rich repeat-containing G-protein-coupled receptor 7,RX1,relaxin/insulin like family peptide receptor 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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