Relaxin receptor 1 (RXFP1) Antibody

Product specifications

Primary Antibodies

Relaxin receptor 1 (RXFP1)

Rabbit

Human

Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

> 95%

Purified by Protein G chromatography.

20 µg

50 µg

100 µg

200 µg

1 mg

Liquid

ELISA, IF/ICC

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9HBX9

RXFP1,LGR7,RXFPR1,relaxin receptor 1,leucine-rich repeat-containing G-protein-coupled receptor 7,RX1,relaxin/insulin like family peptide receptor 1

Antibody anti-RXFP1

RUO

Descripción

RXFP1 is a G protein-coupled receptor activated by relaxin, a peptide hormone involved in reproductive, cardiovascular, and renal physiology. RXFP1 primarily couples to Gs proteins, stimulating adenylate cyclase and increasing intracellular cAMP levels, which in turn affects smooth muscle relaxation, vasodilation, and cell proliferation. RXFP1 is expressed in the reproductive tissues, kidneys, and blood vessels, where it plays a role in pregnancy, cardiac remodeling, and kidney function. During pregnancy, RXFP1 helps modulate uterine relaxation and cervical ripening. In cardiovascular health, RXFP1 is involved in regulating blood pressure and maintaining vascular integrity. Dysregulation of RXFP1 is linked to pregnancy complications, hypertension, and fibrosis. As a target for cardiovascular and renal diseases, RXFP1 receptor agonists are being explored for their potential in promoting tissue repair and reducing fibrosis, while antagonists could be used to modulate pregnancy-related vascular changes.

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