Relaxin Family Peptide/INSL5 Receptor 4 (RXFP4) Antibody

Background

RXFP4, also known as the INSL5 receptor, is a G protein-coupled receptor activated by insulin-like peptide 5 (INSL5), a peptide hormone that plays a role in regulating gastrointestinal function, reproductive physiology, and metabolism. RXFP4 primarily couples to Gs proteins, increasing cAMP levels, and activating pathways involved in smooth muscle relaxation and hormone secretion. It is expressed in the gastrointestinal tract, pancreas, and reproductive organs, where it regulates processes such as intestinal motility, glucose homeostasis, and reproductive function. INSL5 and RXFP4 signaling is involved in the regulation of feeding behavior and insulin secretion. Dysregulation of RXFP4 signaling has been linked to metabolic disorders, such as obesity and type 2 diabetes, and gastrointestinal conditions, including irritable bowel syndrome (IBS). RXFP4 antagonists and agonists are being investigated for their potential therapeutic applications in treating metabolic diseases and gastrointestinal disorders.