G-Protein Coupled Receptor 100 (GPR100) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
G-Protein Coupled Receptor 100 (GPR100) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015249
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against GPR100 protein. Immunogen region is C-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G-Protein Coupled Receptor 100 (GPR100) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TDU9 |
| Alias | RXFP4,RLN3R2,GPCR142,INSL5 receptor,RXFPR4,G protein-coupled receptor 100,relaxin/insulin-like family peptide receptor 4,relaxin/insulin like family peptide receptor 4,GPR100 |
| Background | Antibody anti-RXFP4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
RXFP4, also known as the INSL5 receptor, is a G protein-coupled receptor activated by insulin-like peptide 5 (INSL5), a peptide hormone that plays a role in regulating gastrointestinal function, reproductive physiology, and metabolism. RXFP4 primarily couples to Gs proteins, increasing cAMP levels, and activating pathways involved in smooth muscle relaxation and hormone secretion. It is expressed in the gastrointestinal tract, pancreas, and reproductive organs, where it regulates processes such as intestinal motility, glucose homeostasis, and reproductive function. INSL5 and RXFP4 signaling is involved in the regulation of feeding behavior and insulin secretion. Dysregulation of RXFP4 signaling has been linked to metabolic disorders, such as obesity and type 2 diabetes, and gastrointestinal conditions, including irritable bowel syndrome (IBS). RXFP4 antagonists and agonists are being investigated for their potential therapeutic applications in treating metabolic diseases and gastrointestinal disorders.
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