Recombinant Human RAB18

Background

RAB18, member RAS oncogene family (RAB18) is a small GTPase that plays a critical role in intracellular vesicular trafficking, particularly in lipid metabolism and the regulation of endoplasmic reticulum (ER) dynamics RAB18 is closely involved in the formation of lipid droplets, which are important for the storage and mobilization of lipids within cells It has been implicated in regulating the flow of lipids to various compartments of the cell, including the ER and the Golgi, where they are involved in membrane biosynthesis and protein trafficking RAB18 also plays a significant role in the maintenance of cellular lipid homeostasis and energy metabolism, making it an important protein in adipose tissue and liver function Alterations in RAB18 function are associated with metabolic disorders, including obesity, and certain types of cancer, where defective lipid storage and trafficking contribute to altered cell growth, energy regulation, and tumor development Furthermore, RAB18's role in regulating lipid metabolism links it to diseases related to lipid accumulation, such as non-alcoholic fatty liver disease, where impaired vesicular trafficking disrupts the proper processing of lipids within cells