RAB18 antibody
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935106861
info@markelab.com
name
RAB18 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06999
tested applications
ELISA, WB, IHC, IF
Description
Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB18, member RAS oncogene family (RAB18) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 1G11 |
| Observed MW | 23 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NP72 |
| Gene ID | 22931 |
| Alias | WARBM3,RAB18LI1,Ras-related protein Rab-18 |
| Background | Antibody anti-RAB18 |
| Status | RUO |
| Note | Mol. Weight 23 kDa |
Descripción
RAB18, member RAS oncogene family (RAB18) is a small GTPase that plays a critical role in intracellular vesicular trafficking, particularly in lipid metabolism and the regulation of endoplasmic reticulum (ER) dynamics RAB18 is closely involved in the formation of lipid droplets, which are important for the storage and mobilization of lipids within cells It has been implicated in regulating the flow of lipids to various compartments of the cell, including the ER and the Golgi, where they are involved in membrane biosynthesis and protein trafficking RAB18 also plays a significant role in the maintenance of cellular lipid homeostasis and energy metabolism, making it an important protein in adipose tissue and liver function Alterations in RAB18 function are associated with metabolic disorders, including obesity, and certain types of cancer, where defective lipid storage and trafficking contribute to altered cell growth, energy regulation, and tumor development Furthermore, RAB18's role in regulating lipid metabolism links it to diseases related to lipid accumulation, such as non-alcoholic fatty liver disease, where impaired vesicular trafficking disrupts the proper processing of lipids within cells
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Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.
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