Recombinant Human PAX5
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935106861
info@markelab.com
name
Recombinant Human PAX5
category
Proteins and Peptides
provider
FineTest
reference
P1557
tested applications
Western Blot, ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 140-391 |
| Host | E.Coli |
| Origin | Human |
| Observed MW | 28.6 kDa |
| Expression | Recombinant |
| Purity | Greater than 95% by SDS-PAGE gel analyses |
| Purification | His tag |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
| Tested Applications | Western Blot, ELISA |
| Buffer | Reconstitute with Sterile distilled water |
| Availability | 7 days |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| UniProt ID | Q02548 |
| Alias | ALL3,BSAP,PAX-5,B-cell-specific transcription factor |
| Background | Proteins PAX5 |
| Status | RUO |
| Note | This product is for research use only. |
PAX5 is a critical transcription factor that governs B-cell lineage commitment, differentiation, and survival during hematopoiesis. PAX5 activates B-cell-specific gene expression while repressing alternative lineage programs to ensure B-cell identity. It is expressed in pro-B cells and remains active throughout B-cell maturation, where it regulates immunoglobulin gene rearrangement, signaling, and antigen response. Dysregulation or mutations in PAX5 are commonly observed in B-cell acute lymphoblastic leukemia (B-ALL), where its loss contributes to impaired B-cell differentiation and leukemogenesis. PAX5 also participates in neural and midbrain development during embryogenesis. Knockout models show arrested B-cell development at the pro-B stage and defects in midbrain formation, highlighting its role in both hematopoiesis and neurodevelopment. In cancer, altered PAX5 expression disrupts immune regulation, contributes to lymphomagenesis, and serves as a biomarker for diagnosing B-cell malignancies.
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