Paired Box Protein Pax-5 (PAX5) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Paired Box Protein Pax-5 (PAX5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013173
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against Pax-5 protein. Immunogen region is N-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Paired Box Protein Pax-5 (PAX5) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02548 |
| Alias | ALL3,BSAP,PAX-5,B-cell-specific transcription factor |
| Background | Antibody anti-PAX5 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PAX5 is a critical transcription factor that governs B-cell lineage commitment, differentiation, and survival during hematopoiesis. PAX5 activates B-cell-specific gene expression while repressing alternative lineage programs to ensure B-cell identity. It is expressed in pro-B cells and remains active throughout B-cell maturation, where it regulates immunoglobulin gene rearrangement, signaling, and antigen response. Dysregulation or mutations in PAX5 are commonly observed in B-cell acute lymphoblastic leukemia (B-ALL), where its loss contributes to impaired B-cell differentiation and leukemogenesis. PAX5 also participates in neural and midbrain development during embryogenesis. Knockout models show arrested B-cell development at the pro-B stage and defects in midbrain formation, highlighting its role in both hematopoiesis and neurodevelopment. In cancer, altered PAX5 expression disrupts immune regulation, contributes to lymphomagenesis, and serves as a biomarker for diagnosing B-cell malignancies.
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