Paired Box Protein Pax-5 (PAX5) Antibody

Este producto es parte de PAX - Paired box protein Pax
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52€ (10 µg)

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935106861
info@markelab.com
name
Paired Box Protein Pax-5 (PAX5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013173
tested applications
ELISA, WB

Description

Rabbit polyclonal antibody against Pax-5 protein. Immunogen region is N-terminal.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Paired Box Protein Pax-5 (PAX5)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/3000, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
Size 1
10 µg
Size 2
100 µg
Size 3
200 µg
Size 4
300 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q02548
Alias
ALL3,BSAP,PAX-5,B-cell-specific transcription factor
Background
Antibody anti-PAX5
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

PAX5 is a critical transcription factor that governs B-cell lineage commitment, differentiation, and survival during hematopoiesis. PAX5 activates B-cell-specific gene expression while repressing alternative lineage programs to ensure B-cell identity. It is expressed in pro-B cells and remains active throughout B-cell maturation, where it regulates immunoglobulin gene rearrangement, signaling, and antigen response. Dysregulation or mutations in PAX5 are commonly observed in B-cell acute lymphoblastic leukemia (B-ALL), where its loss contributes to impaired B-cell differentiation and leukemogenesis. PAX5 also participates in neural and midbrain development during embryogenesis. Knockout models show arrested B-cell development at the pro-B stage and defects in midbrain formation, highlighting its role in both hematopoiesis and neurodevelopment. In cancer, altered PAX5 expression disrupts immune regulation, contributes to lymphomagenesis, and serves as a biomarker for diagnosing B-cell malignancies.

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