Recombinant Human ALDOC
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935106861
info@markelab.com
name
Recombinant Human ALDOC
category
Proteins and Peptides
provider
FineTest
reference
P8032
tested applications
Western Blot, ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 1-364 |
| Host | E.Coli |
| Origin | Human |
| Observed MW | 41.3 kDa |
| Expression | Recombinant |
| Purity | Greater than 95% by SDS-PAGE gel analyses |
| Purification | His tag |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose and 0.01% proclin, pH7.4 |
| Tested Applications | Western Blot, ELISA |
| Buffer | Reconstitute with Sterile distilled water |
| Availability | 7 days |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| UniProt ID | P09972 |
| Alias | ALDOC,ALDC |
| Background | Proteins ALDOC |
| Status | RUO |
| Note | This product is for research use only. |
ALDOC is a brain-specific isoform of fructose-bisphosphate aldolase that catalyzes the same glycolytic reaction as ALDOA and ALDOB, converting fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. ALDOC is highly expressed in the central nervous system (CNS), particularly in astrocytes and Purkinje cells of the cerebellum, where it plays a key role in brain energy metabolism and glucose utilization. Altered expression or mutations in ALDOC are linked to neurodegenerative disorders and gliomas, where energy metabolism is disrupted. Additionally, ALDOC is involved in maintaining neuronal function and astrocyte homeostasis under normal and stress conditions. Its critical role in glycolysis makes it essential for supporting brain function and energy demands.
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anti- Aldolase C antibody
Fructose-bisphosphate aldolase C(ALDOC) reversibly cleaves FBP and F1-P to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate and is strongly expressed in mammalian brain together with ALDOA and is alsopresent in the heart and spleen of some species(PMID:9363598). It is involed in glycolysis as an important enzyme. Phospholipase D2 and inositol 1,4,5-triphosphate interact with ALDOC in signal transduction. Meanwhile, the protein expression of ALDOC has been reported to be regulated in brain tumor, hepatomas, and lung cancer(PMID:21548097).
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