Aldolase C, Fructose Bisphosphate (ALDOC) Antibody
292.5€ (80 µl)
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Name
Aldolase C, Fructose Bisphosphate (ALDOC) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx031675
Tested Applications
ELISA, WB, IHC
Description
ALDOC is a member of the fructose-biphosphate aldolase protein family. Expressed specifically in the hippocampus and Purkinje cells of the brain, this protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1, 6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Aldolase C, Fructose Bisphosphate (ALDOC) Immunogen: KLH-conjugated synthetic peptide between 300-333 amino acids from the C-terminal region of human ALDOC. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 39.5 kDa |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09972 |
| NCBI Accession | NP_005156.1 |
| Alias | ALDOC,ALDC |
| Background | Antibody anti-ALDOC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDOC is a brain-specific isoform of fructose-bisphosphate aldolase that catalyzes the same glycolytic reaction as ALDOA and ALDOB, converting fructose-1,6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. ALDOC is highly expressed in the central nervous system (CNS), particularly in astrocytes and Purkinje cells of the cerebellum, where it plays a key role in brain energy metabolism and glucose utilization. Altered expression or mutations in ALDOC are linked to neurodegenerative disorders and gliomas, where energy metabolism is disrupted. Additionally, ALDOC is involved in maintaining neuronal function and astrocyte homeostasis under normal and stress conditions. Its critical role in glycolysis makes it essential for supporting brain function and energy demands.
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