Acyl-CoA Synthetase Short-Chain Family Member 1 (ACSS1) Antibody

Este producto es parte de ACSS - Acyl-CoA Synthetase Short-Chain Family Member
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637€ (100 µl)

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935106861
info@markelab.com
name
Acyl-CoA Synthetase Short-Chain Family Member 1 (ACSS1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110798
tested applications
ELISA, WB

Description

Acyl-Coa Synthetase Short-Chain Family Member 1 Antibody is a Rabbit Polyclonal antibody against Acyl-Coa Synthetase Short-Chain Family Member 1.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Acyl-CoA Synthetase Short-Chain Family Member 1 (ACSS1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NUB1
Gene ID
84532
NCBI Accession
NP_001239604.1, NM_001252675.1, NP_001239605.1, NM_001252676.1, NP_001239606.1, NM_001252677.1, NP_115890.2, NM_032501.3
OMIM
614355
Alias
ACAS2L,ACECS1,AceCS2L
Background
Antibody anti-ACSS1
Status
RUO

Descripción

ACSS1 is a mitochondrial enzyme that activates short-chain fatty acids, primarily acetate, by converting them into acetyl-CoA, which serves as a substrate for the tricarboxylic acid (TCA) cycle, lipid synthesis, and protein acetylation. It is expressed predominantly in tissues with high metabolic demand, such as the liver, heart, and skeletal muscle, where it facilitates energy production and metabolic flexibility. ACSS1 plays a pivotal role in maintaining energy homeostasis during fasting or ketogenic states by metabolizing acetate derived from dietary sources or fatty acid oxidation. Dysregulation of ACSS1 has been linked to metabolic disorders, such as obesity and diabetes, where impaired acetate metabolism affects energy balance and lipid biosynthesis. Its role in mitochondrial acetyl-CoA production underscores its importance in supporting cellular metabolism and adapting to changes in energy availability.

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