Rat Vasoactive Intestinal Peptide Receptor 1 (VIPR1) Protein
234€ (10 µg)
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935106861
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name
Rat Vasoactive Intestinal Peptide Receptor 1 (VIPR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167628
tested applications
WB, SDS-PAGE
Description
VasoactiveIntestinalPeptideReceptor1 Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Vasoactive Intestinal Peptide Receptor 1 (VIPR1) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 16.6 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln34-Gly146 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | VIPR1,Pituitary adenylate cyclase-activating polypeptide type II receptor,PACAP type II receptor,PACAP-R-2,PACAP-R2,VPAC1 |
| Background | Protein VIPR1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
VIPR1 is a G protein-coupled receptor activated by vasoactive intestinal peptide (VIP), a neuropeptide involved in regulating smooth muscle relaxation, vasodilation, and neurotransmission. VIPR1 couples to Gs proteins, stimulating adenylate cyclase and increasing cAMP levels, leading to relaxation of smooth muscle cells, dilation of blood vessels, and modulation of gastrointestinal motility. VIPR1 is primarily expressed in the smooth muscle of the gastrointestinal tract, blood vessels, and the central nervous system, where it plays a role in regulating vascular tone, intestinal motility, and neurotransmitter release. VIP has a significant role in regulating inflammation and immune responses, and VIPR1 signaling is involved in modulating immune cell functions. Dysregulation of VIPR1 signaling has been implicated in inflammatory diseases, gastrointestinal disorders, and cardiovascular diseases. Agonists targeting VIPR1 are being investigated for their potential to treat diseases involving smooth muscle contraction and inflammation, such as asthma, irritable bowel syndrome (IBS), and hypertension.
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