Rat Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) Protein (Active)
1118€ (50 µg)
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Name
Rat Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) Protein (Active)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx693438
Tested Applications
SDS-PAGE
Description
Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) protein is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L3 (UCHL3) |
| Host | E. coli |
| Assay Type | Activity: Active Sequence Fragment: Glu2-Ala230 Tag: N-terminal His tag |
| Origin | Rat |
| Observed MW | 27.5 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q91Y78 |
| Alias | UCH-L3,Ubiquitin thioesterase L3 |
| Background | Protein UCHL3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
UCHL3 is a deubiquitinating enzyme involved in ubiquitin recycling and protein turnover, ensuring cellular protein quality control and homeostasis. It cleaves ubiquitin precursors and removes ubiquitin chains from target proteins, preventing their premature degradation by the proteasome. UCHL3 is ubiquitously expressed and plays roles in DNA repair, apoptosis, and embryonic development. It is particularly essential for spermatogenesis, where it regulates chromatin remodeling and germ cell differentiation. Loss of UCHL3 function is associated with impaired cellular proteostasis, genomic instability, and reproductive defects. Studies show its involvement in tumor progression, where dysregulation of UCHL3 alters protein degradation pathways, contributing to cancer cell survival. Knockout models exhibit defects in germ cell development, growth retardation, and increased sensitivity to cellular stress, underscoring its importance in ubiquitin regulation, cellular stability, and reproductive biology.
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