Rat Myeloproliferative Leukemia Virus Oncogene (MPL) Protein
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Description
Rat c-MPL Protein is a recombinant protein from Rat produced in Baculovirus-Insect Cells. A DNA sequence encoding the mature form of rat MPL (Met1-Ala500) was expressed with a polyhistide tag at the C-terminus.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Myeloproliferative Leukemia Virus Oncogene (MPL) |
| Host | Insect |
| Origin | Rat |
| Observed MW | Molecular Weight: 55.1 kDa Sequence Fragment: Met1-Ala500 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM NaCl, 3mM DTT, 10%glycerol, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | A0A1W2Q6N1, A6JZI7 |
| NCBI Accession | NP_001406773.1 |
| Alias | MPL proto-oncogene, MPLV,TPOR,C-MPL,CD110,THPOR,THCYT2,PO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl |
| Background | Protein MPL |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
MPL, also known as the thrombopoietin receptor, is a critical component in hematopoiesis, particularly for the regulation and production of platelets. It is the cellular receptor for thrombopoietin (TPO), a hormone produced primarily by the liver that promotes the proliferation and maturation of megakaryocytes, the precursors to platelets. MPL is a member of the type I cytokine receptor family and is essential for maintaining platelet counts within physiological ranges. Its activity regulates not only the production of platelets but also has implications in stem cell maintenance and self-renewal within the hematopoietic system. MPL is encoded by the MPL gene located on chromosome 1 (1p34) in humans. Mutations in this gene are associated with various myeloproliferative disorders and hematological diseases, including essential thrombocythemia, primary myelofibrosis, and certain leukemias. Due to its central role in platelet production and stem cell maintenance, MPL is a significant focus of research for understanding hematopoietic disorders and developing targeted therapies.
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