Mouse Thrombopoietin Receptor / CD110 (MPL) Protein
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Description
Recombinant Thrombopoietin Receptor / CD110 (MPL) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Thrombopoietin Receptor / CD110 (MPL) |
| Host | E. coli |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 25.2 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu66-Ser260 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q08351 |
| Gene ID | 17480 |
| Alias | MPL proto-oncogene, MPLV,TPOR,C-MPL,CD110,THPOR,THCYT2,PO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl |
| Background | Protein MPL |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
MPL, also known as the thrombopoietin receptor, is a critical component in hematopoiesis, particularly for the regulation and production of platelets. It is the cellular receptor for thrombopoietin (TPO), a hormone produced primarily by the liver that promotes the proliferation and maturation of megakaryocytes, the precursors to platelets. MPL is a member of the type I cytokine receptor family and is essential for maintaining platelet counts within physiological ranges. Its activity regulates not only the production of platelets but also has implications in stem cell maintenance and self-renewal within the hematopoietic system. MPL is encoded by the MPL gene located on chromosome 1 (1p34) in humans. Mutations in this gene are associated with various myeloproliferative disorders and hematological diseases, including essential thrombocythemia, primary myelofibrosis, and certain leukemias. Due to its central role in platelet production and stem cell maintenance, MPL is a significant focus of research for understanding hematopoietic disorders and developing targeted therapies.
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In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
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