Rat Sirtuin 2 (SIRT2) Protein
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935106861
info@markelab.com
Precio
273€ (10 µg)
Protein SIRT2
proveedor
Abbexareference
abx069101Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat Sirtuin 2 (SIRT2) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
SIRT2 is another NAD+-dependent deacetylase that primarily localizes in the cytoplasm but can translocate to the nucleus under certain conditions to regulate cell cycle progression, metabolism, and oxidative stress SIRT2 deacetylates proteins involved in microtubule dynamics, such as α-tubulin, to maintain cellular morphology and mitotic integrity It also targets transcription factors including FOXO and p53, regulating cell proliferation, apoptosis, and stress resistance SIRT2 has a dual role in tumorigenesis, acting as a tumor suppressor by inhibiting cell proliferation and as a tumor promoter depending on the cellular context SIRT2 plays an essential role in metabolic regulation, particularly during caloric restriction, by modulating gluconeogenesis, insulin sensitivity, and lipid metabolism Dysregulation of SIRT2 has been linked to neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, where it influences protein aggregation and neuronal survival Pharmacological modulation of SIRT2 is under investigation for its therapeutic potential in cancer, metabolic disorders, and neurodegeneration
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Sirtuin 2 (SIRT2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 32.3 kDa Observed MW: 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu28-Leu303 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SIRT2
dry ice
No
availability
Shipped within 5-7 working days.
alias
SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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