Rat Sirtuin 2 (SIRT2) Protein
273€ (10 µg)
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935106861
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name
Rat Sirtuin 2 (SIRT2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069101
tested applications
WB, SDS-PAGE
Description
Rat Sirtuin 2 (SIRT2) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Sirtuin 2 (SIRT2) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 32.3 kDa Observed MW: 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu28-Leu303 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5RJQ4 |
| Alias | SIR2,SIR2L,SIR2L2,NAD-dependent protein deacetylase sirtuin-2 |
| Background | Protein SIRT2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
SIRT2 is another NAD+-dependent deacetylase that primarily localizes in the cytoplasm but can translocate to the nucleus under certain conditions to regulate cell cycle progression, metabolism, and oxidative stress SIRT2 deacetylates proteins involved in microtubule dynamics, such as α-tubulin, to maintain cellular morphology and mitotic integrity It also targets transcription factors including FOXO and p53, regulating cell proliferation, apoptosis, and stress resistance SIRT2 has a dual role in tumorigenesis, acting as a tumor suppressor by inhibiting cell proliferation and as a tumor promoter depending on the cellular context SIRT2 plays an essential role in metabolic regulation, particularly during caloric restriction, by modulating gluconeogenesis, insulin sensitivity, and lipid metabolism Dysregulation of SIRT2 has been linked to neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease, where it influences protein aggregation and neuronal survival Pharmacological modulation of SIRT2 is under investigation for its therapeutic potential in cancer, metabolic disorders, and neurodegeneration
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