Rat Opioid Receptor Kappa 1 (OPRK1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for OPRK1
proveedor
Abbexareference
abx257994Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Opioid Receptor Kappa 1 (OPRK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Opioid Receptor Kappa 1 (OPRK1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
OPRK1, or the kappa-opioid receptor, is a G protein-coupled receptor (GPCR) that binds endogenous opioid peptides such as dynorphins. It is widely expressed in the central nervous system, particularly in regions like the spinal cord, hypothalamus, and limbic system, where it modulates pain, stress responses, and mood. OPRK1 couples to Gi/o proteins, leading to inhibition of adenylate cyclase, decreased cAMP production, and reduced neurotransmitter release. Activation of OPRK1 produces analgesia, particularly in visceral and spinal pain pathways, and induces dysphoria and sedation. OPRK1 also plays a key role in stress-induced behaviors, drug addiction, and depression, where its activation can reduce dopamine release and inhibit reward pathways. Dysregulation of OPRK1 signaling contributes to chronic pain, addiction, and stress-related disorders. Kappa-opioid receptor agonists are being developed as non-addictive analgesics, while antagonists are under investigation for treating mood disorders, addiction, and stress resilience, positioning OPRK1 as a dual therapeutic target.
Características del producto
category
ELISA Kits
immunogen target
Opioid Receptor Kappa 1 (OPRK1)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.06 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
OPRK1,KOR-1,Kappa receptor,OP2,KOP,KOPr,OPRK, K-OR-1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
OPRK1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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