Rat Opioid Receptor Kappa 1 (OPRK1) ELISA Kit

Este producto es parte de OPR - Opioid Receptor
Rat Opioid Receptor Kappa 1 (OPRK1) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for OPRK1

proveedor

Abbexa

reference

abx257994

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Opioid Receptor Kappa 1 (OPRK1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Opioid Receptor Kappa 1 (OPRK1) concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

OPRK1, or the kappa-opioid receptor, is a G protein-coupled receptor (GPCR) that binds endogenous opioid peptides such as dynorphins. It is widely expressed in the central nervous system, particularly in regions like the spinal cord, hypothalamus, and limbic system, where it modulates pain, stress responses, and mood. OPRK1 couples to Gi/o proteins, leading to inhibition of adenylate cyclase, decreased cAMP production, and reduced neurotransmitter release. Activation of OPRK1 produces analgesia, particularly in visceral and spinal pain pathways, and induces dysphoria and sedation. OPRK1 also plays a key role in stress-induced behaviors, drug addiction, and depression, where its activation can reduce dopamine release and inhibit reward pathways. Dysregulation of OPRK1 signaling contributes to chronic pain, addiction, and stress-related disorders. Kappa-opioid receptor agonists are being developed as non-addictive analgesics, while antagonists are under investigation for treating mood disorders, addiction, and stress resilience, positioning OPRK1 as a dual therapeutic target.

Características del producto

category

ELISA Kits


immunogen target

Opioid Receptor Kappa 1 (OPRK1)


reactivity

Rat


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.06 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

OPRK1,KOR-1,Kappa receptor,OP2,KOP,KOPr,OPRK, K-OR-1


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

OPRK1


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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reactivity

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status

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clonality

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