Rat Notch Homolog 4 (NOTCH4) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat Notch Homolog 4 (NOTCH4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167750
tested applications
WB, SDS-PAGE
Description
Notch Homolog 4 Protein is a recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Notch Homolog 4 (NOTCH4) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 30.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr1690-Leu1945 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6MG89 |
| Alias | INT3,notch receptor 4 |
| Background | Protein NOTCH4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Neurogenic locus notch homolog protein 4 (NOTCH4) is a transmembrane receptor in the Notch family, crucial for cell-cell signaling in endothelial cells, where it regulates angiogenesis, vascular remodeling, and homeostasis It encodes a single-pass transmembrane protein with extracellular EGF-like repeats for ligand binding and an intracellular domain (NICD) that translocates to the nucleus upon activation Binding to ligands like Delta-like (DLL) or Jagged triggers proteolytic cleavages by ADAM proteases and gamma-secretase, releasing NICD to activate target genes such as HES and HEY, which control cell proliferation, differentiation, and apoptosis Dysregulation of NOTCH4 signaling is linked to cancers, particularly breast cancer and gliomas, due to its role in angiogenesis and metastasis It also modulates endothelial inflammation and immune responses Mutations or altered expression of NOTCH4 contribute to vascular abnormalities like arteriovenous malformations and pulmonary hypertension Genetic variations in NOTCH4 are associated with schizophrenia and autoimmune diseases like systemic lupus erythematosus, highlighting its importance in development and pathology
Related Products
Human NOTCH4 (Neurogenic locus notch homolog protein 4) ELISA Kit
Ver Producto
Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) Antibody
NOTCH4 Antibody is a Rabbit Polyclonal Antibody against NOTCH4.
Ver Producto
Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) Antibody
Rabbit Polyclonal against the NOTCH4 protein.
Ver Producto