Rat Notch Homolog 4 (NOTCH4) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein NOTCH4
proveedor
Abbexareference
abx167750Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Notch Homolog 4 Protein is a recombinant Rat protein expressed in E. coli.
Background
Neurogenic locus notch homolog protein 4 (NOTCH4) is a transmembrane receptor in the Notch family, crucial for cell-cell signaling in endothelial cells, where it regulates angiogenesis, vascular remodeling, and homeostasis It encodes a single-pass transmembrane protein with extracellular EGF-like repeats for ligand binding and an intracellular domain (NICD) that translocates to the nucleus upon activation Binding to ligands like Delta-like (DLL) or Jagged triggers proteolytic cleavages by ADAM proteases and gamma-secretase, releasing NICD to activate target genes such as HES and HEY, which control cell proliferation, differentiation, and apoptosis Dysregulation of NOTCH4 signaling is linked to cancers, particularly breast cancer and gliomas, due to its role in angiogenesis and metastasis It also modulates endothelial inflammation and immune responses Mutations or altered expression of NOTCH4 contribute to vascular abnormalities like arteriovenous malformations and pulmonary hypertension Genetic variations in NOTCH4 are associated with schizophrenia and autoimmune diseases like systemic lupus erythematosus, highlighting its importance in development and pathology
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Notch Homolog 4 (NOTCH4)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 30.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr1690-Leu1945 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
NOTCH4
dry ice
No
availability
Shipped within 5-7 working days.
alias
INT3,notch receptor 4
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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