Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006119
tested applications
WB
Description
NOTCH4 Antibody is a Rabbit Polyclonal Antibody against NOTCH4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neurogenic Locus Notch Homolog Protein 4 (NOTCH4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99466 |
| Gene ID | 4855 |
| NCBI Accession | NP_004548.3 |
| Alias | INT3,notch receptor 4 |
| Background | Antibody anti-NOTCH4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Neurogenic locus notch homolog protein 4 (NOTCH4) is a transmembrane receptor in the Notch family, crucial for cell-cell signaling in endothelial cells, where it regulates angiogenesis, vascular remodeling, and homeostasis It encodes a single-pass transmembrane protein with extracellular EGF-like repeats for ligand binding and an intracellular domain (NICD) that translocates to the nucleus upon activation Binding to ligands like Delta-like (DLL) or Jagged triggers proteolytic cleavages by ADAM proteases and gamma-secretase, releasing NICD to activate target genes such as HES and HEY, which control cell proliferation, differentiation, and apoptosis Dysregulation of NOTCH4 signaling is linked to cancers, particularly breast cancer and gliomas, due to its role in angiogenesis and metastasis It also modulates endothelial inflammation and immune responses Mutations or altered expression of NOTCH4 contribute to vascular abnormalities like arteriovenous malformations and pulmonary hypertension Genetic variations in NOTCH4 are associated with schizophrenia and autoimmune diseases like systemic lupus erythematosus, highlighting its importance in development and pathology
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