Rat Metabotropic Glutamate Receptor 6 (GRM6) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for GRM6
proveedor
Abbexareference
abx526276Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Metabotropic Glutamate Receptor 6 (GRM6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Metabotropic glutamate receptor 6 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
GRM6, or mGluR6, is a Group III metabotropic glutamate receptor primarily expressed in the retina, where it plays a critical role in visual signal transmission. GRM6 is located on the dendrites of ON bipolar cells, where it couples to Gi/o proteins to inhibit adenylate cyclase, reducing cAMP levels. This pathway is essential for detecting light changes and relaying visual signals from photoreceptors to the brain. Mutations in the GRM6 gene are associated with congenital stationary night blindness (CSNB), a condition characterized by impaired night vision and abnormal signal transduction in the retina. Beyond its role in vision, GRM6 may have limited expression in the CNS, where it could contribute to inhibitory neurotransmission. Given its specialized function in the retina, GRM6 represents a key target for understanding retinal disorders and developing therapies to restore visual signaling in hereditary visual impairments.
Características del producto
category
ELISA Kits
immunogen target
Metabotropic Glutamate Receptor 6 (GRM6)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
GRM6,CSNB1B,GPRC1F,MGLUR6,mGlu6,nob4,nerg1,nob2,nob3
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
GRM6
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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