Rat Metabotropic Glutamate Receptor 6 (GRM6) ELISA Kit
715€ (96 tests)
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Name
Rat Metabotropic Glutamate Receptor 6 (GRM6) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx526276
Tested Applications
ELISA
Description
Rat Metabotropic Glutamate Receptor 6 (GRM6) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Metabotropic glutamate receptor 6 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Metabotropic Glutamate Receptor 6 (GRM6) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P35349 |
| Alias | GRM6,CSNB1B,GPRC1F,MGLUR6,mGlu6,nob4,nerg1,nob2,nob3 |
| Background | Elisa Kits for: GRM6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
GRM6, or mGluR6, is a Group III metabotropic glutamate receptor primarily expressed in the retina, where it plays a critical role in visual signal transmission. GRM6 is located on the dendrites of ON bipolar cells, where it couples to Gi/o proteins to inhibit adenylate cyclase, reducing cAMP levels. This pathway is essential for detecting light changes and relaying visual signals from photoreceptors to the brain. Mutations in the GRM6 gene are associated with congenital stationary night blindness (CSNB), a condition characterized by impaired night vision and abnormal signal transduction in the retina. Beyond its role in vision, GRM6 may have limited expression in the CNS, where it could contribute to inhibitory neurotransmission. Given its specialized function in the retina, GRM6 represents a key target for understanding retinal disorders and developing therapies to restore visual signaling in hereditary visual impairments.
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