Glutamate Metabotropic Receptor 6 (GRM6) Antibody

Background

GRM6, or mGluR6, is a Group III metabotropic glutamate receptor primarily expressed in the retina, where it plays a critical role in visual signal transmission. GRM6 is located on the dendrites of ON bipolar cells, where it couples to Gi/o proteins to inhibit adenylate cyclase, reducing cAMP levels. This pathway is essential for detecting light changes and relaying visual signals from photoreceptors to the brain. Mutations in the GRM6 gene are associated with congenital stationary night blindness (CSNB), a condition characterized by impaired night vision and abnormal signal transduction in the retina. Beyond its role in vision, GRM6 may have limited expression in the CNS, where it could contribute to inhibitory neurotransmission. Given its specialized function in the retina, GRM6 represents a key target for understanding retinal disorders and developing therapies to restore visual signaling in hereditary visual impairments.