Metabotropic glutamate receptor 6 (GRM6) Antibody
169€ (20 µg)
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Name
Metabotropic glutamate receptor 6 (GRM6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx343051
Tested Applications
ELISA, IF/ICC
Description
Metabotropic glutamate receptor 6 (GRM6) Antibody is a Rabbit Polyclonal antibody for the detection of Human GRM6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Metabotropic glutamate receptor 6 (GRM6) Immunogen: Recombinant Human Metabotropic glutamate receptor 6 protein (370-531 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15303 |
| Alias | GRM6,CSNB1B,GPRC1F,MGLUR6,mGlu6,nob4,nerg1,nob2,nob3 |
| Background | Antibody anti-GRM6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GRM6, or mGluR6, is a Group III metabotropic glutamate receptor primarily expressed in the retina, where it plays a critical role in visual signal transmission. GRM6 is located on the dendrites of ON bipolar cells, where it couples to Gi/o proteins to inhibit adenylate cyclase, reducing cAMP levels. This pathway is essential for detecting light changes and relaying visual signals from photoreceptors to the brain. Mutations in the GRM6 gene are associated with congenital stationary night blindness (CSNB), a condition characterized by impaired night vision and abnormal signal transduction in the retina. Beyond its role in vision, GRM6 may have limited expression in the CNS, where it could contribute to inhibitory neurotransmission. Given its specialized function in the retina, GRM6 represents a key target for understanding retinal disorders and developing therapies to restore visual signaling in hereditary visual impairments.
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