Rat Melatonin Receptor 1A (MTNR1A) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat Melatonin Receptor 1A (MTNR1A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx533982
tested applications
ELISA
Description
Rat Melatonin Receptor 1A (MTNR1A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Melatonin receptor type 1A concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Melatonin Receptor 1A (MTNR1A) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P49218 |
| Alias | MTNR1A,mel1a receptor,MelR,MEL-1A-R, MT1 |
| Background | Elisa kits for MTNR1A |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
MTNR1A, also known as MT1, is a G protein-coupled receptor for melatonin, a hormone secreted by the pineal gland that regulates circadian rhythms and sleep-wake cycles. MTNR1A is primarily expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus, where it mediates melatonin’s effects on synchronizing circadian rhythms with environmental light-dark cycles. Activation of MTNR1A inhibits adenylate cyclase via Gi proteins, reducing cAMP levels and modulating downstream signaling pathways that regulate neuronal excitability and gene expression. MTNR1A is critical for sleep initiation, thermoregulation, and seasonal reproduction in some species. Dysregulation of MTNR1A has been associated with sleep disorders, circadian rhythm disturbances, and mood disorders such as depression. MTNR1A agonists like ramelteon are used clinically to treat insomnia and jet lag by promoting sleep onset. Its role in circadian and endocrine regulation highlights MTNR1A as a key target for managing sleep disorders, metabolic health, and mood-related conditions.
Related Products
Human MTNR1A (Melatonin receptor type 1A) ELISA Kit
Ver Producto
MTNR1A antibody
Ver Producto
Melatonin Receptor 1A (MTNR1A) Antibody
Rabbit polyclonal antibody against MTNR1A protein. Immunogen region is Internal.
Ver Producto