Melatonin Receptor 1A (MTNR1A) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Melatonin Receptor 1A (MTNR1A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015347
tested applications
ELISA, IF/ICC
Description
Rabbit polyclonal antibody against MTNR1A protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Melatonin Receptor 1A (MTNR1A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/100 - 1/500, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P48039 |
| Alias | MTNR1A,mel1a receptor,MelR,MEL-1A-R, MT1 |
| Background | Antibody anti-MTNR1A |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
MTNR1A, also known as MT1, is a G protein-coupled receptor for melatonin, a hormone secreted by the pineal gland that regulates circadian rhythms and sleep-wake cycles. MTNR1A is primarily expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus, where it mediates melatonin’s effects on synchronizing circadian rhythms with environmental light-dark cycles. Activation of MTNR1A inhibits adenylate cyclase via Gi proteins, reducing cAMP levels and modulating downstream signaling pathways that regulate neuronal excitability and gene expression. MTNR1A is critical for sleep initiation, thermoregulation, and seasonal reproduction in some species. Dysregulation of MTNR1A has been associated with sleep disorders, circadian rhythm disturbances, and mood disorders such as depression. MTNR1A agonists like ramelteon are used clinically to treat insomnia and jet lag by promoting sleep onset. Its role in circadian and endocrine regulation highlights MTNR1A as a key target for managing sleep disorders, metabolic health, and mood-related conditions.
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