Rat Leucine-Rich Repeat-Containing Protein 26 (LRRC26) ELISA Kit

Product specifications

ELISA Kits

Leucine-Rich Repeat-Containing Protein 26 (LRRC26)

Rat

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q6P7C4

LRRC26, CAPC,Cytokeratin-associated protein in cancer,BK channel auxiliary gamma subunit LRRC26

Elisa kits for LRRC26

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

LRRC26 is a leucine-rich repeat-containing protein that functions as a regulatory subunit of large-conductance calcium-activated potassium (BK) channels, modulating their gating properties and activity. LRRC26 enhances BK channel sensitivity to calcium, allowing activation at lower intracellular calcium concentrations and contributing to processes like membrane potential regulation, ion homeostasis, and smooth muscle relaxation. It is predominantly expressed in tissues such as salivary glands, prostate, and immune cells, where it regulates fluid secretion, smooth muscle tone, and immune cell activation. LRRC26 also plays a role in modulating cell proliferation and survival, particularly in tumor cells, where it promotes BK channel activity to support cell cycle progression and growth. Dysregulation of LRRC26 has been linked to cancer progression, particularly in prostate and breast cancer, where it enhances potassium efflux and supports cell proliferation and migration. Functional studies reveal its importance in fine-tuning BK channel activity, maintaining ionic balance, and regulating cellular excitability under physiological and pathological conditions.

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