Rat Interleukin 4 Receptor (IL4R) Protein

Este producto es parte de IL4R - interleukin 4 receptor
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234€ (10 µg)

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935106861
info@markelab.com
name
Rat Interleukin 4 Receptor (IL4R) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067534
tested applications
WB, SDS-PAGE

Description

Recombinant Interleukin 4 Receptor (IL4R) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Interleukin 4 Receptor (IL4R)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 25.1 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Ile26-Arg232

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q63257
Alias
Interleukin-4 receptor subunit alpha,CD124,IL4RA,IL-4RA,IL-4R subunit alpha,IL-4R-alpha
Background
Protein IL4R
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

The IL4R gene encodes the interleukin-4 receptor alpha (IL-4Rα) subunit, which plays a critical role in the immune system, especially in the regulation of T-helper cell responses. IL-4Rα serves as the receptor for two important cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), both of which influence various aspects of immune and inflammatory responses, including antibody production and the polarization of T-helper cells towards the Th2 phenotype. IL-4R signaling is essential in allergic responses, asthma, and other conditions associated with elevated IgE levels and eosinophilia. IL4Rα exists in both membrane-bound and soluble forms, with the soluble form inhibiting the actions of IL-4 by acting as a decoy receptor. IL4Rα is expressed across several cell types, including T and B lymphocytes, monocytes, macrophages, eosinophils, and endothelial cells. This widespread expression reflects the receptor’s importance in orchestrating responses to pathogens, allergens, and other environmental challenges. Given its central role in modulating immune responses, IL4R has become a target of therapeutic interest, particularly in conditions such as allergic asthma, atopic dermatitis, and certain autoimmune diseases.

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Ver Producto