IL4R antibody
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935106861
info@markelab.com
name
IL4R antibody
category
Primary Antibodies
provider
FineTest
reference
FNab10102
tested applications
ELISA, WB, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 4 receptor (IL4R) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 35 kDa, 120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P24394 |
| Gene ID | 3566 |
| Alias | Interleukin-4 receptor subunit alpha,CD124,IL4RA,IL-4RA,IL-4R subunit alpha,IL-4R-alpha |
| Background | Antibody anti-IL4R |
| Status | RUO |
| Note | Mol. Weight 35 kDa, 120 kDa |
The IL4R gene encodes the interleukin-4 receptor alpha (IL-4Rα) subunit, which plays a critical role in the immune system, especially in the regulation of T-helper cell responses. IL-4Rα serves as the receptor for two important cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13), both of which influence various aspects of immune and inflammatory responses, including antibody production and the polarization of T-helper cells towards the Th2 phenotype. IL-4R signaling is essential in allergic responses, asthma, and other conditions associated with elevated IgE levels and eosinophilia. IL4Rα exists in both membrane-bound and soluble forms, with the soluble form inhibiting the actions of IL-4 by acting as a decoy receptor. IL4Rα is expressed across several cell types, including T and B lymphocytes, monocytes, macrophages, eosinophils, and endothelial cells. This widespread expression reflects the receptor’s importance in orchestrating responses to pathogens, allergens, and other environmental challenges. Given its central role in modulating immune responses, IL4R has become a target of therapeutic interest, particularly in conditions such as allergic asthma, atopic dermatitis, and certain autoimmune diseases.
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