Rat Interferon-Induced GTP-Binding Protein Mx1 (MX1) Protein

Este producto es parte de MX - Interferon-Induced GTP-Binding Protein
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234€ (10 µg)

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935106861
info@markelab.com
name
Rat Interferon-Induced GTP-Binding Protein Mx1 (MX1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167708
tested applications
WB, SDS-PAGE

Description

Rat MX1 Protein is a recombinant Rat protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Interferon-Induced GTP-Binding Protein Mx1 (MX1)
Host
E. coli
Origin
Rat
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 29.9 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Gly68-Leu303 + LEHHHHHH

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P18588
Alias
Interferon-induced protein p78,IFI-78K,Interferon-induced GTP-binding protein Mx1,MXA
Background
Protein MX1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

MX dynamin-like GTPase 1 (MX1), also known as myxovirus resistance protein 1, is a key component of the innate immune response against viral infections. MX1 belongs to the dynamin family of GTPases and exhibits antiviral activity by interfering with the replication of a wide range of RNA viruses, including influenza and vesicular stomatitis viruses. MX1 exerts its effects by targeting viral nucleocapsids, preventing their transport and replication within host cells. MX1 is induced by type I interferons (IFNs), such as IFN-alpha and IFN-beta, upon viral infection. Its GTPase activity is essential for its antiviral function, facilitating conformational changes required to entrap viral components. The protein localizes to the cytoplasm and assembles into ring-like structures, further enhancing its antiviral activity. MX1 is considered a biomarker for interferon signaling and has potential applications in antiviral therapies.

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