Interferon-Induced GTP-Binding Protein Mx1 (MX1) Antibody

Este producto es parte de MX - Interferon-Induced GTP-Binding Protein
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Interferon-Induced GTP-Binding Protein Mx1 (MX1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx025432
tested applications
ELISA, WB

Description

In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Interferon-Induced GTP-Binding Protein Mx1 (MX1)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2b
Purification
Purified through a protein G column, followed by dialysis against PBS.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P20591
Alias
Interferon-induced protein p78,IFI-78K,Interferon-induced GTP-binding protein Mx1,MXA
Background
Antibody anti-MX1
Status
RUO

Descripción

MX dynamin-like GTPase 1 (MX1), also known as myxovirus resistance protein 1, is a key component of the innate immune response against viral infections. MX1 belongs to the dynamin family of GTPases and exhibits antiviral activity by interfering with the replication of a wide range of RNA viruses, including influenza and vesicular stomatitis viruses. MX1 exerts its effects by targeting viral nucleocapsids, preventing their transport and replication within host cells. MX1 is induced by type I interferons (IFNs), such as IFN-alpha and IFN-beta, upon viral infection. Its GTPase activity is essential for its antiviral function, facilitating conformational changes required to entrap viral components. The protein localizes to the cytoplasm and assembles into ring-like structures, further enhancing its antiviral activity. MX1 is considered a biomarker for interferon signaling and has potential applications in antiviral therapies.

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