Rat Docking Protein 1 (DOK1) Protein

Este producto es parte de DOK - Docking protein
Rat Docking Protein 1 (DOK1) Protein

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935106861

info@markelab.com

Precio

234€ (10 µg)

Protein DOK1

proveedor

Abbexa

reference

abx168963

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Rat DOK1 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Docking Protein 1 (DOK1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 28.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly18-Gln237 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DOK1


dry ice

No


availability

Shipped within 5-7 working days.


alias

Downstream of tyrosine kinase 1,P62DOK, pp62


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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