Rat Docking Protein 1 (DOK1) Protein

Pida mas información
935106861
info@markelab.com
Precio
234€ (10 µg)
Protein DOK1
proveedor
Abbexareference
abx168963Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat DOK1 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Docking Protein 1 (DOK1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 28.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly18-Gln237 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
DOK1
dry ice
No
availability
Shipped within 5-7 working days.
alias
Downstream of tyrosine kinase 1,P62DOK, pp62
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
anti- DOK1 antibody

proveedor
FineTestreference
FNab02500Tested Applications
ELISA, WB, IHC, IFreactivity
human,mouse,ratstatus
RUOclonality
polyclonalThe protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The e...
Precio a consultar
Ver másDocking Protein 1 (DOK1) Antibody

proveedor
Abbexareference
abx004349Tested Applications
IHC, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDOK1 Antibody is a Rabbit Polyclonal antibody against DOK1. The protein encoded by this gene is part of a signal transdu...
312€ (60 µl)
Ver másDocking Protein 1 (DOK1) Antibody

proveedor
Abbexareference
abx033622Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (...
292.5€ (80 µl)
Ver más