Rat Docking Protein 1 (DOK1) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Rat Docking Protein 1 (DOK1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx168963
Tested Applications
WB, SDS-PAGE
Description
Rat DOK1 Protein is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Docking Protein 1 (DOK1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gly18-Gln237 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 28.0 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q4QQV2 |
| Alias | Downstream of tyrosine kinase 1,P62DOK, pp62 |
| Background | Protein DOK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Docking protein 1 (DOK1) serves as an adaptor protein involved in cellular signaling pathways, particularly those linked to tyrosine kinase receptors and cytokine receptors. DOK1 lacks intrinsic enzymatic activity but facilitates signal transduction by linking membrane-bound receptors to downstream effectors. It plays a critical role in regulating cell proliferation, differentiation, and apoptosis by acting as a negative regulator of mitogenic signaling pathways. DOK1 is highly expressed in hematopoietic cells and is instrumental in immune responses. Dysregulation of DOK1 has been implicated in oncogenesis, particularly in hematologic malignancies, where it acts as a tumor suppressor by inhibiting excessive cellular proliferation and survival signals. Its interactions with Ras-GAP and other signaling molecules underline its importance in maintaining cellular homeostasis.
Productos relacionados
Docking Protein 1 (DOK1) Antibody
DOK1 Antibody is a Rabbit Polyclonal antibody against DOK1. The protein encoded by this gene is part of a signal transdu…
Ver producto
Docking Protein 1 (DOK1) Antibody
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (…
Ver producto
Docking Protein 1 (DOK1) Antibody (Biotin)
Docking protein 1 Antibody (Biotin) is a Rabbit Polyclonal antibody against Docking protein 1 conjugated to Biotin.…
Ver producto