DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. DOK2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Primary Antibodies
Polyclonal
Human
Docking Protein 1 (DOK1)
Rabbit
Unconjugated
Liquid
ELISA, WB, IHC
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
PBS containing 0.09% sodium azide.
80 µl
400 µl
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
DOK1
No
Shipped within 5-10 working days.
Downstream of tyrosine kinase 1,P62DOK, pp62
This product is for research use only.
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The e...
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Ver másDOK1 Antibody is a Rabbit Polyclonal antibody against DOK1. The protein encoded by this gene is part of a signal transdu...
175€ (20 µl)
Ver másDOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (...
281.25€ (80 µl)
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