Rat C5a anaphylatoxin chemotactic receptor 2 (C5AR2) ELISA Kit

Product specifications

ELISA Kits

C5a anaphylatoxin chemotactic receptor 2 (C5AR2)

Rat

Colorimetric

Quantitative

0.156 ng/ml - 10 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

ELISA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-15 working days. The validity for this kit is 6 months.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

Q695P6

C5AR2,C5L2,C5A receptor beta,complement 5A receptor beta,G protein-coupled receptor 77,GPR77,complement component 5a receptor 2,GPF77

Elisa kits for C5AR2

RUO

Validity: The validity for this kit is 6 months.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

C5AR2, also known as C5L2, is a non-canonical receptor for C5a and its des-Arg derivative (C5a-desArg). Unlike C5AR1, C5AR2 does not couple to G proteins and has been described as a "decoy" or "scavenger" receptor that modulates C5a activity. C5AR2 is expressed on immune cells such as neutrophils, macrophages, and dendritic cells, where it regulates inflammatory responses by sequestering C5a and dampening excessive signaling through C5AR1. However, studies suggest that C5AR2 also exhibits pro-inflammatory roles, enhancing immune cell recruitment, cytokine release, and lipid metabolism under certain conditions. C5AR2 influences signaling through β-arrestin, contributing to pathways like MAPK and ERK, which regulate cell migration and inflammation. Dysregulation of C5AR2 has been implicated in inflammatory and autoimmune diseases, including sepsis, metabolic disorders, and atherosclerosis, where it modulates complement activity and immune cell responses. In cancer, C5AR2 plays a dual role, influencing immune suppression and tumor progression within the tumor microenvironment. C5AR2 remains a target of interest for therapeutic development, particularly in complement-mediated diseases, where modulation of its activity could provide a strategy to balance inflammation and immune regulation.

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