Rat Adenylate kinase 8 (AK8) ELISA Kit
715€ (96 tests)
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935106861
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name
Rat Adenylate kinase 8 (AK8) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx529326
tested applications
ELISA
Description
Rat Adenylate kinase 8 (AK8) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Adenylate kinase 8 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Adenylate kinase 8 (AK8) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q68FP8 |
| Alias | C9orf98,DDX31 |
| Background | Elisa kits for AK8 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AK8, localized in the cytoplasm and nuclear compartments, is a nucleotide kinase involved in nucleotide homeostasis and cellular energy regulation. AK8 specifically catalyzes the phosphotransfer reaction between ATP/GTP and AMP to sustain ATP regeneration. Its nuclear localization highlights a unique role in chromatin remodeling, DNA repair, and RNA synthesis processes, where energy supply is tightly regulated. AK8 expression is particularly enriched in rapidly dividing cells, such as immune cells, stem cells, and certain cancer cells, supporting proliferation and metabolic reprogramming. Dysregulation of AK8 has been associated with tumorigenesis due to its role in maintaining nucleotide pools for DNA replication. In neurons, AK8 also regulates energy homeostasis, influencing processes such as neurotransmitter synthesis and synaptic plasticity. Knockdown studies suggest that AK8 depletion results in reduced energy metabolism, impaired mitochondrial function, and disrupted cell cycle progression. AK8 has recently emerged as a target in cancer metabolism research, given its pivotal role in energy supply under hypoxic and nutrient-deprived environments.
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