Rat ABCA1 (ATP Binding Cassette Transporter A1) ELISA Kit
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Name
Rat ABCA1 (ATP Binding Cassette Transporter A1) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
ER1451
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 0.156-10ng/ml |
| Sensitivity | 0.094ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | F1LNL3 |
| Alias | TGD,ABC1,CERP,ABC-1,HDLDT1,HPALP1,HDLCQTL13 |
| Background | Elisa kits for ABCA1 |
| Status | RUO |
Background
ABCA1 is a transmembrane protein belonging to the ATP-binding cassette (ABC) transporter family, playing a vital role in lipid metabolism and cellular cholesterol efflux. It facilitates the transport of cholesterol and phospholipids from cells to apolipoproteins, such as ApoA-I, in the plasma, which is a critical step in the formation of high-density lipoprotein (HDL). Structurally, ABCA1 consists of two transmembrane domains and two ATP-binding domains that utilize ATP hydrolysis to drive lipid transport. It is highly expressed in macrophages, hepatocytes, and other cells involved in lipid metabolism. The activity of ABCA1 is essential for maintaining cellular cholesterol homeostasis and preventing lipid accumulation, particularly in macrophages, where its dysfunction can lead to foam cell formation and atherosclerosis. Mutations in the ABCA1 gene are associated with Tangier disease, a rare disorder characterized by very low HDL levels and increased susceptibility to cardiovascular disease. As a key regulator of cholesterol efflux and HDL biogenesis, ABCA1 is a therapeutic target for managing dyslipidemia and cardiovascular risk.
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